The Rat Anti-Histone H3 Antibody from MyBioSource.com is a Rat Monoclonal antibody to H3 Histone, Family 3A, and H3F3A. This antibody recognizes Human antigen. The Rat Anti-Histone H3 Antibody has been validated for the following applications: Flow Cytometry, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
H3 is a core component of the nucleosome that serves to wrap and compact DNA into chromatin.Histones therefore, limit the accessibility of DNA, providing mechanisms for transcription regulation, DNA repair and replication and chromosomal stability.During mitosis, H3 is phosphorylated at serine 28.This phosphorylation coincides with chromosome condensation initiated at prophase and disappears at late anaphase H3 has been demonstrated to be phosphorylated by the action of MLTK-a (mixed linage kinase-like mitogen activated protein triple kinase a) in response to ultraviolet B light and epidermal growth factor, as well as Aurora-B during mitosis